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Popular Anti-Cholesterol Drugs Could Slow Prostate Cancer Progression
Prostate cancer patients who take statins to lower their cholesterol may be getting a secondary benefit: The drugs significantly lower the degree of inflammation within prostate tumors.
That, according to researchers, may explain in part, why men on statins have a lower risk of disease progression.
Previous studies have shown that statins reduce systemic inflammation. In this instance, researchers from Duke University were interested in finding out if the drugs reduced inflammation inside tumors -- so-called intra-tumoral inflammation -- that is believed to contribute to cancer recurrence after surgery.
"We found that preoperative statin use was associated with a 69% lower risk of intra-tumoral inflammation," says Lionel Bañez, an assistant professor of surgery and urology at Duke and the study's lead author. "We also discovered a trend suggesting greater risk-reduction with higher doses of the drugs."
In the study, which appears online in the journal Cancer Epidemiology, Biomarkers & Prevention, researchers examined tissue samples of tumors from 236 men undergoing surgery for prostate cancer at the Durham (N.C.) VA Medical Center.
Researchers identified the samples as coming from statin users or non-users, tracked the dose and frequency among the users, and graded the degree of inflammation in the tissue samples as absent, mild, or marked.
They found that 16% of the patients took statins during the year prior to surgery. Most (92%) were using simvastatin. Eighty-two percent of the patients had inflammatory cells in their prostate tumors, with roughly one-third registering marked tumor inflammation.
After taking into consideration factors such as age, race, body mass index and other clinical variables, investigators found statin use was associated with reduced inflammation within the tumors.
They also found that inflammation was more likely among older patients with more advanced cancers and who had experienced a longer time from biopsy to surgery.
"Increasing evidence suggests that statins may reduce risk of prostate cancer progression, and some studies have even suggested that widespread statin use over the past 15 years has contributed to a decline in prostate cancer mortality," says Bañez.
So should all prostate cancer patients be on a statin? "No -- or at least not yet," says Stephen Freedland, associate professor of urology and pathology in the Duke Prostate Center and the study's senior author. "More studies have to be done before such a recommendation can be made. However, men taking statins for heart health may already be enjoying a beneficial side effect against prostate cancer."
"If these findings are validated in additional studies, it would support the hypothesis that statins delay prostate cancer progression, in part, by reducing inflammation inside the tumor," Bañez says.
It has long been known that statins have benefits beyond lowering cholesterol. Recent studies suggest they could lower the risk of infection, slow the progression of Alzheimer's and help prevent miscarriages.
(Article courtesy of ConsumerAffairs.com)
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